Emerging Trends in Effervescent Granules: From Conventional Formulation to Novel Drug Delivery System: A Review

Purpose: Widely used pharmaceutical dosages form are effervescent granules designed to improve bioavailability, drug dissolution and improve the patient compliance. This review provide a brief overview of modern formulation approaches and highlights the recent improvement in effervescent granules based delivery. Effervescent granule a widely used pharmaceutical dosages form designed to improve bioavailability, drug dissolution and improve patient compliance. This review provide a comprehensive overview of conventional formulation approaches and highlights the recent advantages in effervescent granule based delivery system. Methods: A comprehensive review of published literature, including research articles, review paper, and pharmaceutical text, was conducted. The collected data were analysed with respect of formulation principles, evaluation parameter, and recent technological advancement in effervescent systems. Results: Effervescent granules work on the function of acid base reaction that generates carbon dioxide when it come in contact with the water result in rapid disintegration and enhanced drug dissolution. This system offers rapid onset of action, enhanced palatability and better patient compliance. Recent innovation include control-release formulation, gastro retentive floating system, nanotechnology-based approaches and 3D printing techniques, have substantially expanded pharmaceutical application and therapeutic prospect. Conclusion: Effervescent granule portray a versatile and developing drug delivery system that bridges conventional formulation with modern pharmaceutical approach. Continuous advancement are expected to further improve their stability, efficacy and role in patient centric and personalized drug delivery system.