Key result
Mitral valve replacement with annular reconstruction successfully resolves rapidly enlarging caseous mitral annular calcification.
Why the study?
Caseous calcification of the mitral annulus is a rare variant of mitral annular calcification associated with diagnostic difficulty and an increased risk of embolic stroke.
Case Report (n=1)
No
Surgical debridement and mitral valve replacement can effectively treat rapidly progressing caseous calcification of the mitral annulus in hemodialysis patients.
Supports surgical consideration for enlarging caseous calcification in hemodialysis; leaves open need for prospective validation beyond case reports.
Caseous calcification of the mitral annulus (CCMA) is a rare variant of mitral annular calcification associated with an increased risk of embolic stroke and diagnostic difficulty. We report a surgical case of CCMA that showed rapid enlargement after the initiation of hemodialysis. A 71-year-old woman undergoing hemodialysis for 1 year presented with a rapidly enlarging mass at the P3 segment of the posterior mitral annulus. Echocardiography and computed tomography revealed a calcified mass with a hypoechoic/low-attenuation core. Intraoperatively, the lesion contained creamy caseous material, and mitral valve replacement with annular reconstruction was required after debridement. Histopathology confirmed CCMA without malignancy or infection. CCMA may progress rapidly in patients on hemodialysis, likely due to disordered calcium-phosphorus metabolism and chronic inflammation. Early surgical intervention with complete isolation of caseous material may help prevent systemic embolism.
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Mori et al. (2026) conducted a case report in Caseous calcification of the mitral annulus (CCMA) (n=1). Mitral valve replacement with annular reconstruction was evaluated on Postoperative outcome. Mitral valve replacement with annular reconstruction successfully treated a rapidly enlarging caseous calcification of the mitral annulus without postoperative complications.
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