Key result
JenaValve Trilogy enables successful TAVI with no paravalvular leak in severe native AR from perforation.
Why the study?
Severe native aortic regurgitation due to cusp perforation after healed infective endocarditis presents challenges for TAVI, particularly without annular calcification.
Does transfemoral TAVI using the JenaValve Trilogy system improve hemodynamics in a patient with severe native aortic regurgitation due to cusp perforation after healed infective endocarditis?
Case Report (n=1)
No
Does transfemoral TAVI using the JenaValve Trilogy system improve hemodynamics in a patient with severe native aortic regurgitation due to cusp perforation after healed infective endocarditis?
TAVI using a leaflet-anchoring system with active deflection can be a feasible option for prohibitive-risk patients with severe native aortic regurgitation due to cusp perforation from healed endocarditis.
Answers are grounded in this paper and cite their sources.
May support TAVI feasibility in prohibitive-risk native AR from cusp perforation; leaves open durability, safety, and generalizability in larger cohorts.
BACKGROUND: Severe native aortic regurgitation due to cusp perforation after healed infective endocarditis presents challenges for transcatheter aortic valve implantation (TAVI), particularly without annular calcification. CASE SUMMARY: A 46-year-old patient with healed infective endocarditis presented with severe eccentric aortic regurgitation due to perforation of the left coronary cusp. Given prohibitive surgical risk, transfemoral TAVI using the JenaValve Trilogy system was performed. Controlled deflection and rotational repositioning enabled coaxial alignment of the valve above the native cusps prior to deployment, resulting in no paravalvular leak and excellent hemodynamic outcome. DISCUSSION: This case highlights the technical challenges of TAVI in aortic regurgitation with cusp perforation and demonstrates how leaflet-locator anchoring, delivery system deflection, and multimodality imaging enable safe and effective valve positioning. TAKE-HOME MESSAGE: Cusp perforation may cause locator misengagement during TAVI; controlled deflection and repositioning are critical to achieve safe, stable deployment.
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Chan et al. (2026) conducted a case report in Severe native aortic regurgitation after healed infective endocarditis (n=1). Transfemoral TAVI using the JenaValve Trilogy system was evaluated on Procedural success and hemodynamic outcome. Transfemoral TAVI using the JenaValve Trilogy system achieved successful deployment with no paravalvular leak and excellent hemodynamics in a patient with severe native aortic regurgitation due to cusp perforation.
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