Combined therapy with liraglutide and deferoxamine produced superior restoration of ventricular function and antioxidant defenses against doxorubicin-induced cardiotoxicity in rats.
Does the combination of liraglutide and deferoxamine prevent doxorubicin-induced cardiotoxicity in a rat model?
The combination of liraglutide and deferoxamine synergistically protects against doxorubicin-induced cardiotoxicity in a rat model by targeting iron overload and antioxidant signaling.
Doxorubicin (Dox) is a highly effective chemotherapeutic agent whose clinical utility is limited by dose-dependent cardiotoxicity, largely driven by iron overload-dependent cell death (ferroptosis) and excessive reactive oxygen species (ROS). Targeting ferroptosis represents a promising strategy for cardioprotection. This study investigated the cardioprotective potential of liraglutide (Lira), deferoxamine (DFO), and their combination in a rat model of Dox-induced cardiotoxicity. Male Wistar rats received Dox (20 mg/kg, i.p.) following pretreatment with Lira (200 μg/kg/day), DFO (50 mg/kg/week), or their combination for 3 weeks. Cardiac injury markers, iron homeostasis, oxidative stress indices, ferroptosis-related gene expression, and histopathological alterations were evaluated. Dox administration induced marked cardiac dysfunction, elevated CK-MB and troponin-T, disrupted iron regulation, increased lipid peroxidation, suppressed Nrf-2/GPX-4 signaling, and triggered ferroptosis. Both Lira and DFO significantly attenuated these alterations; however, combined therapy produced superior restoration of ventricular function, normalization of iron parameters, enhancement of antioxidant defenses, and preservation of myocardial architecture. These findings demonstrate that simultaneous targeting of iron overload and antioxidant signaling confers enhanced cardioprotection against Dox-induced injury. The Lira–DFO combination may represent a promising adjunct strategy to mitigate anthracycline-associated cardiotoxicity.
Monir et al. (Sat,) conducted a other in Doxorubicin-induced cardiotoxicity. Liraglutide and deferoxamine combination vs. Doxorubicin alone or monotherapy was evaluated on Cardiac injury markers, iron homeostasis, oxidative stress indices, ferroptosis-related gene expression, and histopathological alterations. Combined therapy with liraglutide and deferoxamine produced superior restoration of ventricular function and antioxidant defenses against doxorubicin-induced cardiotoxicity in rats.