Key result
Liraglutide produced robust cardioprotection and increased survival in mice lacking cardiomyocyte GLP-1R following LAD coronary artery occlusion.
Why the study?
Does liraglutide improve survival and LV remodeling in cardiomyocyte-specific GLP-1R knockout mice following ventricular injury?
Population
Glp1r global knockout mice and Glp1r cardiomyocyte-specific knockout mice subjected to myocardial infarction…
Design
Preclinical
Authors
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GLP-1R knockout in cardiomyocytes does not affect post-MI remodeling or survival; challenges direct cardiomyocyte mediation of GLP-1R agonist benefits.
Does liraglutide improve survival and LV remodeling in cardiomyocyte-specific GLP-1R knockout mice following ventricular injury?
Cardiomyocyte GLP-1R is essential for basal heart rate control but is not required for the cardioprotective and survival benefits of GLP-1R agonists like liraglutide following ischemic injury.
Ussher et al. (2014) studied Myocardial infarction and doxorubicin-induced cardiomyopathy. Liraglutide was evaluated on Survival and left ventricular remodeling. Liraglutide produced robust cardioprotection and increased survival in mice lacking cardiomyocyte GLP-1R following LAD coronary artery occlusion.
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