Why the study?
Does genetic deletion or pharmacological inhibition of DPP-4 improve cardiovascular outcomes after myocardial infarction in mice?
Population
Normoglycemic and diabetic mice undergoing experimental myocardial infarction or ischemia-reperfusion injury
Comparison
Genetic deletion of DPP-4 or pharmacological… vs Wild-type littermate controls or metformin…
Design
Preclinical
Authors
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Should not change clinical practice; leaves open potential benefits of DPP-4 inhibition in diabetic post-MI patients pending human trials.
Does genetic deletion or pharmacological inhibition of DPP-4 improve cardiovascular outcomes after myocardial infarction in mice?
Genetic disruption or chemical inhibition of DPP-4 does not impair cardiovascular function and improves survival and functional recovery after myocardial infarction in murine models.
Sauvé et al. (2010) studied this question.
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