Key result
Intravenous pilsicainide induced premature ventricular complexes and polymorphic ventricular tachycardia in a patient with atypical Brugada syndrome.
Case Report (n=1)
Pilsicainide infusion can trigger premature ventricular complexes and polymorphic ventricular tachycardia in patients with atypical Brugada syndrome presenting with inferior ST-segment elevation.
Pilsicainide may provoke VT in adolescents with atrial flutter and subtle ST changes; hypothesis-generating case report requiring prospective validation.
A 17-year-old man was referred to our hospital for treatment of common paroxysmal atrial flutter. His electrocardiogram at rest showed subtle ST-segment elevation in leads II, III, and aV(F). Intravenous pilsicainide caused further ST-segment elevation in the inferior leads, new ST-segment depression in leads V2-V6, two distinct forms of premature ventricular complexes (PVCs) triggering short runs of polymorphic ventricular tachycardia (VT). An infusion of isoproterenol suppressed these arrhythmias and normalized the ST-segment. Pilsicainide may induce PVCs and polymorphic VT in atypical Brugada syndrome.
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Chinushi et al. (2006) conducted a case report in Common paroxysmal atrial flutter with inferior ST-segment elevation (n=1). Intravenous pilsicainide was evaluated. Intravenous pilsicainide induced premature ventricular complexes and polymorphic ventricular tachycardia in a patient with atypical Brugada syndrome.
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