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ABSTRACT Objective The aim of this study was to determine which cognitive patient reported outcome measure (PROM) best represents self‐reported cognitive functioning in real‐world environments among breast cancer survivors (BCS) as measured by ecological momentary assessments (EMA), and to compare their ability to predict future everyday functioning. Methods One‐hundred twenty‐four BCS (ages 24–88) completed self‐report measures of cognitive functioning (FACT‐Cog PCI, PROMIS Cog, CFQ, EORTC‐CF) and everyday functioning (SDI, FACT‐G Functional Well‐being subscale) at baseline (Time 1) and at 9 weeks follow up (Time 2). Between assessments, EMA protocols (including one item to assess cancer‐related cognitive symptoms) were administered every other day for 8 weeks. Person‐specific means and standard deviations were calculated for EMA data. Hierarchical linear regression models were used to model cognitive PROM predictors of person‐specific averages and variability in EMAs, SDI, and FACT‐G functional well‐being, and model parameters ( R 2 , AIC, BIC, semi‐partial R) were compared. Results Follow‐up FACT‐Cog PCI most accurately predicted both the average (Δ R 2 = 0.213, p < 0.001) and variability (Δ R 2 = 0.071, p < 0.001) in EMA CRCI symptoms. For future functional outcomes, the PROMIS Cog and FACT‐Cog PCI at baseline demonstrated similar predictive power for Time 2 Functional Well‐being (Δ R 2 = 0.210, p < 0.001). Additionally, baseline FACT‐Cog PCI was the strongest predictor of social dysfunction (SDI; Δ R 2 = 0.205, p < 0.001). Conclusions These findings support the ecological validity of cognitive PROMs in BCS and indicate that both FACT‐Cog PCI and PROMIS Cog effectively capture real‐world cognitive symptoms and predict future everyday functioning, including social function and well‐being.
Henneghan et al. (Sat,) studied this question.