Key result
Sertraline was superior to placebo on HAMD and CGI-S/CGI-I in older adults with major depressive disorder, with a faster time to response in those with medical comorbidities (P<0.006).
Why the study?
Does sertraline improve depressive symptoms in elderly patients with major depressive disorder, regardless of comorbid medical illness?
Population
752 patients aged 60 and older with a diagnosis of major depressive disorder according to DSM-IV, with and…
Comparison
Sertraline vs Placebo
Design
RCT, Randomized, Double-blind
Authors
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Supports sertraline for late-life MDD with or without comorbidities; extends RCT evidence to comorbid subgroups.
RCT (n=752)
Double-blind
Randomized
Yes
Does sertraline improve depressive symptoms in elderly patients with major depressive disorder, regardless of comorbid medical illness?
Sertraline is an effective and well-tolerated treatment for late-life depression, including in patients with comorbid medical illnesses.
Sheikh et al. (2003) conducted an RCT in Major depressive disorder (n=752). Sertraline vs. Placebo was evaluated on 17-item Hamilton Depression Scale (HAMD) and Clinical Global Depression-Severity/Improvement (CGI-S/CGI-I). Sertraline was superior to placebo on HAMD and CGI-S/CGI-I in older adults with major depressive disorder, with a faster time to response in those with medical comorbidities (P<0.006).
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