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To explore the role of sigma 1 receptor activation in preserving cone photoreceptor function in a mouse model of inherited retinal degeneration.

Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration

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To explore the role of sigma 1 receptor activation in preserving cone photoreceptor function in a mouse model of inherited retinal degeneration.
Used Pde6β(rd10) mice as a model for retinal degeneration.
Administered the sigma 1 receptor ligand (+)-pentazocine to rd10 mice over several weeks.
Assessed cone function through electroretinographic recordings, optical coherence tomography, and retinal histology.
Systemic treatment with (+)-PTZ rescued cone function as shown by electroretinography.
Treatment preserved cone cells in rd10 mice, whereas rd10/Sig1R(-/-) mice showed no preservation after (+)-PTZ administration.
(+)-PTZ reduced oxidative stress and attenuated reactive gliosis and microglial activation in the retinas.

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Randomized trial demonstrates preservation of cone function in a murine model of retinal degeneration, suggesting a new treatment approach.

Wang et al. (2016) studied this question.

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Randomized trial demonstrates preservation of cone function in a murine model of retinal degeneration, suggesting a new treatment approach.