Key result
Convection-enhanced delivery of adeno-associated virus vectors allows for safe, targeted, and homogeneous distribution of gene therapy across the blood-brain barrier for neurological disorders.
Design
Review
Authors
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Gene therapy vectors show promise for neurological disorders; leaves open clinical translation pending prospective trials.
This review highlights the potential of convection-enhanced delivery of adeno-associated virus vectors for targeted gene therapy in neurological disorders.
Lonser et al. (2020) conducted a review in Neurological disorders. Convection-enhanced delivery of adeno-associated virus gene therapy was evaluated. Convection-enhanced delivery of adeno-associated virus vectors allows for safe, targeted, and homogeneous distribution of gene therapy across the blood-brain barrier for neurological disorders.
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