Key result
Sex functions as a modifier of thrombosis and response to antithrombotic therapy, driven by differences in procoagulant protein expression and platelet function.
Why the study?
How does sex modify the mechanisms of thrombosis and the response to antithrombotic therapy?
How does sex modify the mechanisms of thrombosis and the response to antithrombotic therapy?
This review highlights critical sex-based differences in thrombosis mechanisms and emphasizes that men and women may not derive equal benefit from standard antithrombotic therapies.
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Sex-specific antithrombotic evaluation needed in trials; leaves open translation of animal differences to human outcomes.
Bailey et al. (2009) conducted a review in Arterial and venous thrombosis. Sex (female vs male) was evaluated. Sex functions as a modifier of thrombosis and response to antithrombotic therapy, driven by differences in procoagulant protein expression and platelet function.