Why the study?
Hypertensive disorders of pregnancy contribute significantly to maternal morbidity, mortality, and long-term cardiovascular disease risk, motivating the identification of circulating proteins associated with them.
Do genetic instruments for cardiovascular disease-related proteins associate with the risk of gestational hypertension and preeclampsia?
Population
European-ancestry females from GWAS meta-analyses for gestational hypertension and preeclampsia and 21 758 SCALLOP participants
Comparison
Genetic instruments for 90 cardiovascular disease-related candidate proteins vs outcomes
Design
Two-sample mendelian randomization study
Key result
Genetically predicted levels of four cardiovascular proteins (CD40, ECP, Gal-3, NT-proBNP) were robustly associated with gestational hypertension, and two (CSTB, HSP27) with preeclampsia.
Authors
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Circulating protein associations with HDPs via MR need validation; leaves open causal roles in pregnancy hypertension.
Observational (n=606,903)
Yes
Do genetic instruments for cardiovascular disease-related proteins associate with the risk of gestational hypertension and preeclampsia?
Genetic instruments for specific cardiovascular proteins, including NT-proBNP and HSP27, are associated with the risk of gestational hypertension and preeclampsia, suggesting potential therapeutic targets.
Schuermans et al. (2024) conducted an observational in Gestational hypertension and preeclampsia (n=606,903). Genetically predicted circulating cardiovascular disease-related proteins vs. Unexposed/reference genetic profile was evaluated on Gestational hypertension and preeclampsia. Genetically predicted levels of four cardiovascular proteins (CD40, ECP, Gal-3, NT-proBNP) were robustly associated with gestational hypertension, and two (CSTB, HSP27) with preeclampsia.