Photodynamic therapeutic activities of tri-bromine porphyrins: Effect of nitrogen position on the pyridine

This study focuses on the synthesis of tri-bromine containing asymmetric porphyrins for their use as photosensitizers in photodynamic therapy and photodynamic antimicrobial chemotherapy. The porphyrins were modified in various ways including quaternization which introduced a positive charge. The photophysical and photochemical properties were investigated and the porphyrins have good singlet oxygen quantum yields. The photodynamic therapeutic activities of the complexes were tested against MDA-MB-231 breast cancer cell lines and Escherichia Coli. Some of the complexes showed some good activity against the considered targets.