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This research aims to understand how a maternal high-fat diet influences fetal liver development and metabolic risk factors.

Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates

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This research aims to understand how a maternal high-fat diet influences fetal liver development and metabolic risk factors.
Investigated the effects of chronic high-fat diet on fetal metabolic systems in nonhuman primates.
Compared fetal liver health in offspring from lean versus obese mothers consuming high-fat diets.
Analyzed hepatic triglycerides, oxidative stress, and enzyme expression in relation to maternal diet.
Fetal offspring from high-fat diet mothers had a 3-fold increase in liver triglycerides.
O-HFD animals showed increased oxidative stress and elevated gluconeogenic enzyme expression.
Reversal to a low-fat diet in subsequent pregnancies improved fetal liver triglyceride levels.

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Randomized trial shows lipotoxic effects on fetal livers in nonhuman primates, suggesting risks for metabolic diseases.

McCurdy et al. (2009) studied this question.

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