Key result
Use of prothrombin complex concentrates for warfarin-related intracerebral haemorrhage reversal was associated with a significantly lower risk of death (HR 0.27; P<0.01).
Why the study?
Does prothrombin complex concentrate (PCC) improve survival in patients with warfarin-related intracerebral haemorrhage?
Population
88 patients presenting with warfarin-related intracerebral haemorrhage between January 2004 and July 2010
Comparison
Prothrombin complex concentrates for warfarin… vs Warfarin reversal without PCC
Design
Cohort
Authors
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May support PCC reversal in warfarin-related ICH; leaves open randomized confirmation of survival benefit.
Cohort (n=88)
Does prothrombin complex concentrate (PCC) improve survival in patients with warfarin-related intracerebral haemorrhage?
Hazard Ratio: 0.27
p-value: p=<0.01
In patients with warfarin-related intracerebral hemorrhage, reversal with prothrombin complex concentrates significantly improved survival without worsening functional outcomes.
Hanger et al. (2012) conducted a cohort in Warfarin-related intracerebral haemorrhage (n=88). Prothrombin complex concentrates (PCC) vs. No PCC was evaluated on Death (HR 0.27, p=<0.01). Use of prothrombin complex concentrates for warfarin-related intracerebral haemorrhage reversal was associated with a significantly lower risk of death (HR 0.27; P<0.01).
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