Key result
Higher acute lipid responses to mental stress predicted higher fasting lipid levels and significantly greater odds of clinically elevated cholesterol 3 years later.
Why the study?
Does acute lipid stress responsivity predict fasting serum lipid levels 3 years later in middle-aged men and women?
Cohort (n=199)
Does acute lipid stress responsivity predict fasting serum lipid levels 3 years later in middle-aged men and women?
Acute lipid stress responsivity independently predicts fasting lipid levels 3 years later, suggesting a potential mechanism for the development of elevated blood cholesterol.
Lipid reactivity to mental stress was associated with later hypercholesterolemia; hypothesis-generating and should not yet change practice.
The authors assessed the association between lipid responses to acute mental stress and fasting serum lipid levels 3 years later in 199 middle-aged men and women. Total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol increased following moderately stressful behavioral tasks. LDL cholesterol, HDL cholesterol, and total:HDL ratio measured 3 years later were predicted by acute stress responses independent of gender, age, socioeconomic position, change in body mass, smoking, alcohol consumption, or hormone replacement therapy baseline lipid levels. The odds of clinically elevated cholesterol were significantly greater in the highest compared with the lowest stress tertile, independent of baseline levels and covariates. Acute lipid stress responsivity may reflect processes that contribute to the development of elevated blood cholesterol concentration.
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Steptoe et al. (2005) reported a cohort. Acute lipid stress responses vs. Lowest stress tertile was evaluated on Fasting serum lipid levels and clinically elevated cholesterol at 3 years. Higher acute lipid responses to mental stress predicted higher fasting lipid levels and significantly greater odds of clinically elevated cholesterol 3 years later.
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