Key result
Bone marrow mononuclear cell injection improves cell survival and preserves fractional shortening versus other cell types.
Why the study?
A comparative analysis of the efficacy of different adult stem cell types for treating myocardial ischemia had not been described.
Does intramyocardial injection of different adult stem cell types improve cell survival and cardiac function in a murine model of myocardial infarction?
Does intramyocardial injection of different adult stem cell types improve cell survival and cardiac function in a murine model of myocardial infarction?
p-value: p=<0.05
In a murine model of myocardial infarction, bone marrow mononuclear cells exhibited better survival and more robust preservation of cardiac function compared to mesenchymal stem cells, skeletal myoblasts, and fibroblasts.
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MN superior in murine MI survival; leaves open optimal cell candidate for human trials.
Bogt et al. (2008) studied myocardial infarction (n=70). Bone marrow mononuclear cells (MN) vs. MSC, SkMb, Fibro, or PBS was evaluated on Cell survival and cardiac function (p=<0.05). Intramyocardial injection of bone marrow mononuclear cells exhibited better cell survival at 6 weeks (P<0.01) and preserved fractional shortening (P<0.05) compared to other cell types and PBS.
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