What question did this study set out to answer?

To develop a non-invasive method for monitoring drug release in the gastrointestinal tract using novel microcarriers.

March 10, 2017Nature CommunicationsOpen Access

In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers

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Randomized trial monitors gastrointestinal drug release in real-time, suggesting innovative drug delivery strategies.

To develop a non-invasive method for monitoring drug release in the gastrointestinal tract using novel microcarriers.
Developed a microcarrier that retains drugs and resists gastrointestinal conditions.
Utilized fluorescence signals in the second near-infrared window for real-time monitoring.
Measured drug release and microcarrier retention in vivo over 72 hours.
Tracked microcarrier fate and monitored up to 62% of drug content released in vivo.
Achieved prolonged residence time of microcarriers in the gastrointestinal tract for 72 hours.
Minimal deposition of microcarriers in non-target organs, like liver and kidney.

Wang et al. (2017) studied this question.

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