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May 1, 1974Journal of Research of the National Bureau of Standards Section A Physics and ChemistryOpen Access

An improved procedure for synthesis of DL-4-hydroxy-3-methoxymandelic acid (DL-""vanillyl""-mandelic acid, VMA)

Alexander J. Fatiadi Robert Schaffer

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Abstract

An improved procedure for synthesis of DL-4-Hydroxy-3-methoxymandelic Acid (DL-Vanillyl-mandelic Acid, VMA) entails slow addition of an ice-cold, aqueous solution of glyoxylic acid to an ice-cold alkaline solution of guaiacol, with efficient mechanical stirring. This one-step condensation procedure provides VMA in 68-75 percent yield.

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Fatiadi et al. (1974) studied this question.

synapsesocial.com/papers/6a5be91219e8c79e69b98788 https://doi.org/10.6028/jres.078a.024

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