Key result
Apatite coating reduces simvastatin release by ~25% from biomimetic drug delivery systems.
Simvastatin have been shown to induce bone formation and there is currently a urgent need to develop an appropriate delivery system to sustain the release of the drug to increase therapeutic efficacy whilst reducing side effects. In this study, a novel drug delivery system for simvastatin by means of hydrothermally converting marine exoskeletons to biocompatible beta-tricalcium phosphate was investigated. Furthermore, the release of simvastatin was controlled by the addition of an outer apatite coating layer. The samples were characterized by x-ray diffraction analysis, fourier transform infrared spectroscopy, scanning electron microscopy and mass spectroscopy confirming the conversion process. The in-vitro dissolution of key chemical compositional elements and the release of simvastatin were measured in simulated body fluid solution showing controlled release with reduction of approximately 25% compared with un-coated samples. This study shows the potential applications of marine structures as a drug delivery system for simvastatin.
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Chou et al. (2013) studied this question. Biomimetic β-TCP with outer apatite coating vs. Un-coated samples was evaluated on Release of simvastatin in simulated body fluid (approximately 25% reduction). The addition of an outer apatite coating to a biomimetic β-TCP drug delivery system reduced the in-vitro release of simvastatin by approximately 25% compared with un-coated samples.
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