Why the study?
Despite lifestyle modifications and current pharmacotherapy, blood pressure remains inadequately controlled in the majority of hypertensive individuals.
Design
Review
Key result
Novel antihypertensive medications, including aprocitentan, aldosterone synthase inhibitors, and zilebesiran, offer new therapeutic mechanisms for improving blood pressure control.
Authors
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May expand options for resistant hypertension; hypothesis-generating pending outcome trials.
Novel antihypertensive classes, including endothelin receptor antagonists, aldosterone synthase inhibitors, and RNA-based therapies, offer promising new options for improving blood pressure control.
Jackson et al. (2026) conducted a review in Hypertension. Novel antihypertensive medications (aprocitentan, aldosterone synthase inhibitors, zilebesiran) was evaluated. Novel antihypertensive medications, including aprocitentan, aldosterone synthase inhibitors, and zilebesiran, offer new therapeutic mechanisms for improving blood pressure control.
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