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December 21, 2004Angewandte Chemie International Edition216 citations

Palladium‐Catalyzed Asymmetric Allylation of Prochiral Nucleophiles: Synthesis of 3‐Allyl‐3‐Aryl Oxindoles

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BTBarry M. TrostMFMathias Frederiksen

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Abstract

Excellent yields and enantioselectivies are attained in the synthesis of 3-alkyl-3-aryl oxindoles based on the Pd-catalyzed asymmetric allylic alkylation (AAA) reaction. This approach utilizes a nonbasic hydroxylic additive in the transformation of 3-aryl oxindoles into complex, synthetically valuable oxindoles (see scheme).

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Cite This Study

Trost et al. (2004) studied this question.

synapsesocial.com/papers/6a5bf40e9544c3549673b586https://doi.org/10.1002/anie.200460335
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