Why the study?
Does low-dose aspirin prevent vascular events in patients with type 2 diabetes mellitus?
Population
Patients with type 2 diabetes mellitus
Design
Review
Key result
Low-dose aspirin prophylaxis in patients with diabetes is associated with a non-significant decrease in the risk of vascular events, with variable response linked to platelet COX-1 turnover rates.
Authors
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May inform COX-1 turnover-guided personalization; leaves open aspirin's role in diabetes primary prevention.
Does low-dose aspirin prevent vascular events in patients with type 2 diabetes mellitus?
Understanding mechanisms of residual platelet hyper-reactivity, such as variable COX-1 turnover, may help personalize anti-platelet strategies for primary prevention in diabetes.
Santilli et al. (2015) conducted a review in Type 2 diabetes mellitus. Low-dose aspirin was evaluated. Low-dose aspirin prophylaxis in patients with diabetes is associated with a non-significant decrease in the risk of vascular events, with variable response linked to platelet COX-1 turnover rates.