Key result
Covid-19 infection was associated with reduced ejection fraction in 36% of survivors and abnormal global longitudinal strain with normal ejection fraction in 22% at one month post-discharge.
Why the study?
Cardiac dysfunction and myocarditis are established complications of Covid-19, but they have not been sufficiently studied in Indian patients using echocardiography or other imaging modalities.
Does 2D-echocardiography with GLS imaging identify subclinical myocardial dysfunction in Covid-19 survivors?
Cross-Sectional (n=100)
Does 2D-echocardiography with GLS imaging identify subclinical myocardial dysfunction in Covid-19 survivors?
p-value: p=<0.002
Myocardial dysfunction is common in Covid-19 survivors regardless of disease severity, and 2D-echocardiography with GLS can detect early subclinical LV dysfunction.
GLS may detect subclinical LV dysfunction in COVID-19 survivors; hypothesis-generating and should not yet change practice.
BACKGROUND: Covid-19 is multi-system viral infection caused by SARS-CoV-2 virus. Apart from having acute severe respiratory illness causing high mortality, the disease also has a variety of cardiovascular manifestations contributing to morbidity as well as mortality. Cardiac dysfunction and myocarditis are well established complications of Covid-19 as evident in multiple studies after the Covid-19 pandemic. However it is not sufficiently studied in Indian patients either by Echocardiography or by any other imaging modalities like cardiac magnetic resonance imaging (MRI). METHODOLOGY: In this study, we analysed the severity of Left ventricular(LV) dysfunction in Covid-19 survivors. A total of 100 consecutive patients of Covid-19 after one month of discharge who had no underlying cardiovascular diseases underwent echocardiography and global longitudinal strain (GLS) imaging. This study cohort included patients with mild 42 (42%),moderate 46(46%) and severe 12(12%) Covid-19 disease as defined by computerised tomography (CT) severity score. RESULT: We observed that total 36(36%) patients had reduced ejection fraction(EF) which included 11 patients having EF <40% and remaining 25(25%) having EF 40-50% (p<0.002). Also 22 (22%) patients had abnormal global longitudinal strain (GLS) values with normal ejection fraction which is suggestive of subclinical myocarditis. We observed LV dysfunction in 7(19.5%) patients who had severe Covid-19 while mild to moderate LV dysfunction observed in 29(80.5%) non critical patients. CONCLUSION: In conclusion our study demonstrates that myocardial dysfunction is common in covid-19 regardless of disease severity. 2D-echocardiography with GLS is likely to detect early LV dysfunction among these patients.
No takes yet. Share an insight, caveat, or question.
Kujur et al. (2021) conducted a cross-sectional in Covid-19 (n=100). Covid-19 infection was evaluated on Reduced ejection fraction (p=<0.002). Covid-19 infection was associated with reduced ejection fraction in 36% of survivors and abnormal global longitudinal strain with normal ejection fraction in 22% at one month post-discharge.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: