Key result
Periprocedural optimization and risk management improve functional outcomes in frail older patients with aortic stenosis.
Why the study?
Care of older aortic stenosis patients is often constrained by concomitant frailty and aging-associated comorbidities that limit functional improvement after valve intervention, making periprocedural optimization and risk management crucial.
This review highlights the importance of addressing frailty and concurrent aging-associated diseases in older patients undergoing TAVR to optimize periprocedural care and outcomes.
May inform frailty-focused TAVR protocols in older patients; leaves open prospective validation of outcome benefits.
Degenerative aortic stenosis (AS) is an aging-associated disease with alarmingly high mortality that has risen in prevalence in tandem with the global population aging. Treatment options for AS are currently limited to surgical or percutaneous valve intervention, which are associated with significant morbidity. It is increasingly recognized that the care of AS patients is frequently constrained by concomitant frailty, an under-recognized syndrome among older individuals. Many AS patients have concurrent aging-associated diseases, including atherosclerotic diseases, organ impairment, physical frailty, and nutritional deficiencies which limit functional improvement after valve intervention. It has become increasingly crucial for clinicians to address these concurrent issues in frail, older individuals with AS to achieve the best possible outcomes. We aim to review the well-studied relationship between frailty and AS, as well as possible strategies for periprocedural optimization and risk management.
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Eng et al. (2025) conducted a review in Degenerative aortic stenosis and frailty. Periprocedural optimization and risk management was evaluated. Periprocedural optimization and risk management are crucial for frail older patients with aortic stenosis to address concurrent aging-associated diseases and improve functional outcomes.
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