Key result
Computed tomography-derived fractional flow reserve (FFRCT) is a validated noninvasive surrogate for invasive FFR that serves as a gatekeeper to invasive angiography and reduces downstream costs.
Why the study?
Additional knowledge of the extent and distribution of myocardial ischemia enables tailored management in patients with chest pain evaluated with computed tomography coronary angiography.
What is the current clinical utility and future direction of computed tomography-derived fractional flow reserve (FFRCT) in patients with chest pain?
What is the current clinical utility and future direction of computed tomography-derived fractional flow reserve (FFRCT) in patients with chest pain?
Answers are grounded in this paper and cite their sources.
FFRCT provides combined anatomical and physiological assessment from standard CTCA data, serving as an effective non-invasive gatekeeper to invasive coronary angiography.
Computed tomography coronary angiography is emerging as the preferred diagnostic tool for patients with chest pain. Additional knowledge of the extent and distribution of myocardial ischemia enables tailored patient management. Computed tomography-derived fractional flow reserve (FFRCT) employs computed tomography coronary angiography raw data processed via complex computational fluid dynamics and produces a surrogate of the invasive fractional flow reserve (FFR) thus delivering anatomical and physiological assessment in a single test. FFRCT has been extensively validated against invasive FFR and observational clinical studies have consistently demonstrated its utility as gatekeeper to invasive angiography while also reducing downstream clinical events and costs. Novel workstation-based models of estimating FFR are now being tested. Ongoing and future research results will define their role in clinical practice.
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Gabara et al. (2020) conducted a review in Chest pain and myocardial ischemia. Computed tomography-derived fractional flow reserve (FFRCT) vs. Invasive fractional flow reserve (FFR) was evaluated. Computed tomography-derived fractional flow reserve (FFRCT) is a validated noninvasive surrogate for invasive FFR that serves as a gatekeeper to invasive angiography and reduces downstream costs.
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