Key result
Fractional flow reserve derived from CT (FFR CT) is superior to coronary CT angiography alone for diagnosing ischemia-causing lesions, primarily by reducing false-positive rates.
Why the study?
Does FFR CT improve diagnostic accuracy for ischemia-causing lesions compared to CTA alone?
Does FFR CT improve diagnostic accuracy for ischemia-causing lesions compared to CTA alone?
Answers are grounded in this paper and cite their sources.
FFR CT enhances the diagnostic accuracy of standard coronary CTA by reducing false positives, particularly in patients with intermediate coronary stenosis.
OBJECTIVE. The purpose of this article is to discuss recent technologic innovations that enable noninvasive calculation of fractional flow reserve (FFR) from CT. CONCLUSION. FFR CT is superior to coronary CT angiography (CTA) stenosis for the diagnosis of ischemia-causing lesions. FFR CT improves the diagnostic accuracy mostly by reducing the false-positive rates incorrectly classified by CTA stenosis alone. Furthermore, in patients in whom CT shows an intermediate stenosis-wherein the results of CT alone are the most clinically ambiguous for ischemia diagnosis-FFR CT shows significantly higher diagnostic performance than CT alone.
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Precious et al. (2015) conducted a review in Ischemia-causing lesions. Fractional flow reserve from CT (FFR CT) vs. Coronary CT angiography (CTA) stenosis alone was evaluated on Diagnosis of ischemia-causing lesions. Fractional flow reserve derived from CT (FFR CT) is superior to coronary CT angiography alone for diagnosing ischemia-causing lesions, primarily by reducing false-positive rates.
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