Key result
Fractional flow reserve derived from computed tomography angiography (FFRCT) provides an accurate, noninvasive anatomical and functional assessment of coronary lesions, reducing unnecessary invasive procedures.
FFRCT is a noninvasive diagnostic method that provides both anatomical and functional assessment of the coronary tree without requiring additional radiation or hyperemic agents compared to routine CCTA.
Invasively determined fractional flow reserve (FFR) represents the gold-standard method for the functional evaluation of coronary lesions. Coronary computed tomography angiography (CCTA) provides characterization of the coronary anatomy, with important morphological information on the atherosclerotic plaques, but does not offer a hemodynamic evaluation of coronary artery lesions. CT evaluation of FFR (FFRCT) is a new noninvasive diagnostic method, which provides anatomical and functional assessment of the whole coronary tree, based on computational techniques, with no more radiation or hyperemic agent administration compared with routine CCTA. Recent studies demonstrated the safety and accuracy of FFRCT and its therapeutic use and cost benefits in real-world clinical use.
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Mester et al. (2016) conducted a review in Coronary artery disease. Fractional flow reserve derived from CCTA (FFRCT) vs. Invasive coronary angiography and standard CCTA was evaluated. Fractional flow reserve derived from computed tomography angiography (FFRCT) provides an accurate, noninvasive anatomical and functional assessment of coronary lesions, reducing unnecessary invasive procedures.
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