Key result
A modified ratchet model revealed that the maximum efficiency of collective myosin II motors depends on elasticity and is independent of transition rates.
Why the study?
The study was conducted to investigate the efficiency of collective non-processive motors such as myosin II in muscle using a modified ratchet model including power-stroke and elastic coupling.
A modified ratchet model reveals that the maximum efficiency of collective myosin II motors depends on elasticity and differs between fast and slow muscle types.
Model parameters differ for fast vs slow muscle; leaves open elasticity tuning for cardiac myosin efficiency.
We proposed a modified ratchet model including power-stroke and elastic coupling to study the efficiency of collective non-processive motors such as myosin II in muscle. Our theoretical results are in good agreement with the experimental data. Our study not only reveals that the maximum efficiency depends on elasticity and is independent of transition rates but also indicates that the parameters fitted to fast muscle are different from those fitted to a slow one. The latter may imply that the structure of the fast muscle is different from that of the slow one. The main reason that our model succeeds is that velocity in this model is an independent variable.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2018) studied Myosin II motor efficiency. Modified ratchet model including power-stroke and elastic coupling was evaluated on Maximum efficiency of collective non-processive motors. A modified ratchet model revealed that the maximum efficiency of collective myosin II motors depends on elasticity and is independent of transition rates.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: