A validation method for near-infrared spectroscopy based tissue oximeters for cerebral and somatic tissue oxygen saturation measurements

arterial saturation values following a similar protocol, with sensors place on the flank, quadriceps muscle, and calf muscle. With informed consent, 25 subjects successfully completed the cerebral validation study. The bias and precision (1 SD) of cerebral StO 2 compared to REF CX B was -0.14 3.07%. With informed consent, 24 subjects successfully completed the somatic validation study. The bias and precision of somatic StO 2 compared to REF CX S was 0.04 4.22% from the average of flank, quadriceps, and calf StO 2 measurements to best represent the global whole body REF CX S . The NIRS validation methods presented potentially provide a reliable means to test NIRS monitors and qualify them for clinical use.