Key result
In intact functioning rat hearts, acute L-CPT1 overexpression reduced acetyl CoA production from palmitate (69% vs 79% with PBS, P<0.05), recapitulating the phenotype of cardiac hypertrophy.
Absolute Event Rate: 69% vs 79%
p-value: p=<0.05
Acute L-CPT1 overexpression in non-diseased adult rat hearts reduces palmitate oxidation and induces hypertrophic signaling, recapitulating the metabolic phenotype of cardiac hypertrophy.
L-CPT1 overexpression may initiate hypertrophic signaling via reduced fatty acid oxidation in rats; leaves open relevance to human cardiomyopathy.
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Lewandowski et al. (2012) studied Cardiac hypertrophy (n=27). Adv.cmv.L-CPT1 (L-CPT1 expression) vs. Phosphate-buffered saline (PBS) or empty virus was evaluated on Acetyl CoA production from palmitate (p=<0.05). In intact functioning rat hearts, acute L-CPT1 overexpression reduced acetyl CoA production from palmitate (69% vs 79% with PBS, P<0.05), recapitulating the phenotype of cardiac hypertrophy.
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