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This research aims to understand how interactions between left- and right-handed polylysine chains promote β-sheet aggregation.

The Diastereomeric Assembly of Polylysine Is the Low-Volume Pathway for Preferential Formation of β-Sheet Aggregates

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This research aims to understand how interactions between left- and right-handed polylysine chains promote β-sheet aggregation.
Analyzed the transition temperatures of poly(D-lysine) and poly(L-lysine) mixtures compared to single enantiomer systems.
Investigated the volume changes and heat capacity during the α-helix to β-sheet transition.
Evaluated the thermodynamic implications of diastereomeric aggregation.
Observed a 15 degrees C decrease in the α-helix to β-sheet transition temperature for the mixture.
Noted a relative volume expansion of 13-19 mL x mol(-1) for single enantiomers that did not occur in the mixture.
Identified substantially more negative heat capacity changes, indicating lower solvent-entropy costs as a driving force.

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Randomized trial shows the impact of polylysine interactions on β-sheet formation, suggesting new insights into amyloid diseases.

Dzwolak et al. (2004) studied this question.

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