Key result
EV71 infection in children was associated with decreased frequencies of total Th, Tc, and Treg cells (P<0.01), and increased percentages of B, Th2, and Th17 cells (P<0.01) compared to controls.
Why the study?
Enterovirus 71 is a major cause of hand, foot, and mouth disease, and immune cells determine infection outcomes, but lymphocyte subsets and T-cell transcription factors in infected children required characterization.
Does EV71 infection alter the frequencies of lymphocyte subsets and transcription factors in children?
Population
32 children with EV71 infection and 32 control subjects
Comparison
Children with EV71 infection vs control subjects
Authors
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EV71 infection in children causes significant shifts in peripheral blood lymphocyte subsets, characterized by decreased Th, Tc, and Treg cells and increased B, Th2, and Th17 cells.
Case-Control (n=64)
Does EV71 infection alter the frequencies of lymphocyte subsets and transcription factors in children?
p-value: p=< 0.01
EV71 infection in children causes significant shifts in peripheral blood lymphocyte subsets, characterized by decreased Th, Tc, and Treg cells and increased B, Th2, and Th17 cells.
Zhao et al. (2019) conducted a case-control in EV71 infection (n=64). EV71 infection vs. Control subjects was evaluated on Frequencies of T-, B-lymphocytes, and their subsets (p=< 0.01). EV71 infection in children was associated with decreased frequencies of total Th, Tc, and Treg cells (P<0.01), and increased percentages of B, Th2, and Th17 cells (P<0.01) compared to controls.
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