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The d-miniprotein DPDI-49, developed via mirror-image phage display, effectively inhibits the PD-1/PD-L1 interaction with nanomolar affinity, demonstrating that well-folded miniprotein libraries are superior to short peptide libraries for targeting challenging protein-protein interfaces. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Discovery of d -Miniprotein Inhibitors of PD-1/PD-L1 Interaction via Mirror-Image Phage Display against Synthetic d -PD-1

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