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Synthesis strategies produce bicyclo[2.1.1]hexanes, suggesting potential for enhanced cyclobutane properties.
Strategies for the synthesis of 5,6-disubstituted bicyclo[2.1.1]hexanes are presented. These target molecules are of high value because we propose that they might act as rigidified variants of 1,3-disubstituted cyclobutanes. Key to the strategy is the use of a photochemical Wolff rearrangement. Several diastereoselective transformations are provided to showcase their utility.
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Paul et al. (2026) studied this question.
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