What question did this study set out to answer?

This research aims to evaluate the impact of lymphocyte recovery trajectories on mortality among sepsis patients with initial lymphopenia.

July 19, 2026PLoS ONEOpen Access

Failure of early lymphocyte recovery identifies sepsis patients with initial lymphopenia at highest risk for late mortality

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This research aims to evaluate the impact of lymphocyte recovery trajectories on mortality among sepsis patients with initial lymphopenia.
Retrospective cohort study using data from the MIMIC-IV database.
Group-Based Trajectory Modeling identified lymphocyte count trajectories.
Kaplan-Meier analysis and multivariable regression assessed the association between trajectories and mortality outcomes.
Trajectory 4 (Persistent Low Level) showed significantly increased 28-day mortality (adjusted HR = 1.76, 95% CI: 1.266–2.446, P = 0.001).
Trajectory 4 also associated with higher ICU mortality (adjusted OR = 1.831, 95% CI: 1.196–2.832, P = 0.006) and in-hospital mortality (adjusted OR = 1.881, 95% CI: 1.298–2.767, P = 0.001).
No significant association was observed between Trajectory 4 and 7-day mortality after full adjustment for confounders.

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Implication

Retrospective cohort study finds lymphocyte count trajectories predict late mortality in sepsis patients, suggesting potential therapeutic strategies.

Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/6a5c69fb118b92953e3ee249 https://doi.org/10.1371/journal.pone.0353698

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Implication

Retrospective cohort study finds lymphocyte count trajectories predict late mortality in sepsis patients, suggesting potential therapeutic strategies.

Failure of early lymphocyte recovery identifies sepsis patients with initial lymphopenia at highest risk for late mortality

Key Points

Discussion

Implication

Cite This Study

Failure of early lymphocyte recovery identifies sepsis patients with initial lymphopenia at highest risk for late mortality

Key Points

Discussion

Implication

Cite This Study

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