Ticagrelor Removal From Human Blood

Figures

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  Figure 1. Experimental Setup for Ticagrelor Removal From BSA Solution and Human Blood Experimental setup for ticagrelor removal from BSA solution (A) and human blood (B). BSA, bovine serum albumin.

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  Figure 2. Removal Rate of Ticagrelor From a 4% BSA Solution Removal rate of ticagrelor from a 4% BSA solution using various volumes of sorbent—CytoSorb (A) and Porapak Q 50-80 mesh (B)—in a first-pass experiment. Abbreviation as in Figure 1.

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  Figure 3. Removal Rate of Ticagrelor From Whole Human Blood Removal rate of ticagrelor from whole human blood purchased from a blood bank during a recirculating experiment using CytoSorb in 2 models, on 14 10-ml columns mounted in series (model 1) (A) or 1 300-ml column (model 2) (B).

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  Figure 4. Removal Rate of Ticagrelor From Whole Human Blood and Plasma Removal rate of ticagrelor from whole human blood (A) and plasma (B) freshly (<60-min interval until being used) collected during model 3 of the blood recirculating experiment using CytoSorb.

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  Figure 5. Comparison of Ticagrelor and AR-C124910XX Structures Comparison of ticagrelor (A) and main metabolite AR-C124910XX (B) structures.