Key result
Metabolically unhealthy status and an abnormal myocardial perfusion scintigraphy study were independently associated with increased all-cause mortality (HR 1.72 and 1.85, respectively), whereas body mass index was not.
Why the study?
Does myocardial perfusion scintigraphy effectively stratify all-cause mortality risk in metabolically healthy versus unhealthy obese and nonobese patients?
Population
2,450 patients, stratified by obesity and metabolic health.
Comparison
Myocardial perfusion scintigraphy categorization… vs Nonobese patients, and normal MPS findings.
Design
Cohort
Follow-up
4.0 ± 1.0 years
Authors
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Observational data link MU status to higher mortality; leaves open independent prognostic value beyond MPS and does not support practice change.
Cohort (n=2,450)
No
Does myocardial perfusion scintigraphy effectively stratify all-cause mortality risk in metabolically healthy versus unhealthy obese and nonobese patients?
Hazard Ratio: 1.72 (95% CI 1.02–3.1)
p-value: p=0.04
Myocardial perfusion scintigraphy effectively stratifies mortality risk across obese and nonobese patients regardless of metabolic health status, with normal scans indicating a uniformly low risk of death.
Lorenzo et al. (2018) conducted a cohort in Obesity and metabolic health (n=2,450). Metabolically unhealthy status vs. Metabolically healthy status was evaluated on All-cause death (HR 1.72, 95% CI 1.02-3.1, p=0.04). Metabolically unhealthy status and an abnormal myocardial perfusion scintigraphy study were independently associated with increased all-cause mortality (HR 1.72 and 1.85, respectively), whereas body mass index was not.
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