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Recent studies demonstrate that obese adipose tissue is characterized by macrophage infiltration, which serves as an important source of inflammation and may contribute to insulin resistance.
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Highlights new evidence that macrophage infiltration is a major driver of chronic inflammation in obese adipose tissue.
Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity.
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Wellen et al. (2003) conducted an editorial in Obesity and Type 2 Diabetes. Recent studies demonstrate that obese adipose tissue is characterized by macrophage infiltration, which serves as an important source of inflammation and may contribute to insulin resistance.
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