Key result
High and low stress hyperglycemia ratios linked to ~35% higher post-discharge mortality in CHD.
Why the study?
Although stress hyperglycemia ratio is associated with adverse outcomes in hospitalized ACS patients, its role in long-term prognosis remains controversial.
Is the stress hyperglycemia ratio (SHR) associated with post-discharge all-cause mortality in patients with coronary heart disease?
Cohort (n=5,273)
No
Is the stress hyperglycemia ratio (SHR) associated with post-discharge all-cause mortality in patients with coronary heart disease?
Hazard Ratio: 1.35 (95% CI 1.03–1.77)
p-value: p=0.031
Both low and high stress hyperglycemia ratios are associated with increased post-discharge all-cause mortality in patients with coronary heart disease, suggesting a need for optimal glycemic management.
SHR shows U-shaped mortality link in CHD; hypothesis-generating and should not yet change practice.
BACKGROUND: Stress hyperglycemia ratio (SHR) has been associated with adverse clinical outcomes in hospitalized patients with acute coronary syndromes (ACS). However, its role in long-term prognosis remains controversial. This study aims to investigate the correlation between SHR and post-discharge all-cause mortality in coronary heart disease (CHD) patients. METHODS: A retrospective cohort analysis was conducted on a comprehensive dataset encompassing 5,273 coronary heart disease (CHD) patients from The First Affiliated Hospital of Shantou University Medical College, spanning from January 2020 to April 2024. The study introduced a novel parameter, Stress hyperglycemia ratio (SHR), calculated using the formula: SHR =[Formula: see text]. Cox regression analysis, smooth curve fitting techniques, and subgroup analyses were employed to evaluate associations. RESULTS: During a maximum follow-up of 1,649 days, 8.1% of patients experienced all-cause mortality. After multivariable adjustments, a U-shaped association emerged between SHR and mortality risk (HR = 1.35, 95%CI= (1.03 ~ 1.77), P = 0.031). Both low and high SHR levels were linked to increased mortality. CONCLUSIONS: SHR demonstrates a U-shaped association with post-discharge all-cause mortality in CHD patients, highlighting the need for glycemic management within an optimal range.
No takes yet. Share an insight, caveat, or question.
Liang et al. (2025) conducted a cohort in Coronary heart disease (CHD) (n=5,273). Stress hyperglycemia ratio (SHR) vs. Optimal SHR range (Quartile 3) was evaluated on All-cause mortality (HR 1.35, 95% CI 1.03-1.77, p=0.031). Stress hyperglycemia ratio demonstrated a U-shaped association with post-discharge all-cause mortality in patients with coronary heart disease, with both low and high levels linked to increased risk.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: