Key result
The incidence of sudden cardiac death among 1- to 35-year-olds in Sweden was 1.3 per 100,000 person-years, with sudden arrhythmic death syndrome being the most common etiology.
Observational (n=552)
Effect estimate: 11% yearly decrease in women (95% CI 6.6-14.2)
Sudden arrhythmic death syndrome is the most common cause of sudden cardiac death among young individuals in Sweden, with an overall incidence of 1.3 per 100,000 person-years.
Provides national SCD incidence benchmarks in youth; leaves open generalizability and preventive implications pending prospective data.
AIMS: To study the incidence and aetiology of sudden cardiac death (SCD) in 1- to 35-year-olds in Sweden from 2000 to 2010. METHODS AND RESULTS: We used the database of the Swedish National Board of Forensic Medicine and the Swedish Cause of Death Registry and identified SCD cases by review of forensic files and death certificates. We identified 552 individuals with SCD in 1- to 35-year-olds; 156 (28%) were women. In 393 (71%), a forensic autopsy had been performed; in 131 (24%), a clinical autopsy had been performed; in 28 (5%) with no autopsy, a cardiac disease was diagnosed before death. The incidence of SCD per 100 000 person-years was 1.3 in 1- to 35-year-olds and 1.8 in 15- to 35-year-olds. In women, the incidence rates yearly decreased during the study period by 11% (95% confidence interval 6.6-14.2). The most common aetiology in 1- to 35-year-olds was sudden arrhythmic death syndrome (31%) and coronary artery disease (15%). In cases with forensic autopsy, death occurred during daily activity (48%), sleep (38%), and physical activity (14%); death was unwitnessed in 60%. Co-morbidity in 15- to 35-year-olds, e.g. psychiatric disorder, obesity, or diabetes, was present in 93/340 (27%) (73 men). CONCLUSION: The incidence of SCD among 1- to 35-year-olds in Sweden during 2000-10 was 1.3 per 100 000 person-years (28% women); incidence was decreasing in women. Sudden arrhythmic death syndrome was the most common diagnosis. Co-morbidity such as psychiatric disorders and obesity was common among men.
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Wisten et al. (2016) conducted an observational in Sudden cardiac death (n=552). General population aged 1-35 years was evaluated on Incidence of sudden cardiac death per 100,000 person-years (11% yearly decrease in women, 95% CI 6.6-14.2). The incidence of sudden cardiac death among 1- to 35-year-olds in Sweden was 1.3 per 100,000 person-years, with sudden arrhythmic death syndrome being the most common etiology.
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