Key result
A novel tissue slicing method for isolating human cardiomyocytes achieved a 64.8% yield of viable, rod-shaped cells that retained intact morphology, contractility, and metabolic responses.
Population
Human cardiac tissue
Design
Preclinical
Authors
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May enable mature human cardiomyocyte disease modeling; leaves open validation versus iPSC models before research adoption.
A novel method for isolating primary human cardiomyocytes from tissue slices provides a robust cellular model with improved viability and preserved physiological functions.
Guo et al. (2018) studied Cardiovascular diseases (Heart failure, Hypertrophic cardiomyopathy, Normal) (n=36). Modified tissue slicing and isolation method was evaluated on Rod-shaped cell yield. A novel tissue slicing method for isolating human cardiomyocytes achieved a 64.8% yield of viable, rod-shaped cells that retained intact morphology, contractility, and metabolic responses.
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