Key result
Recent infection, inflammatory conditions, moderate-heavy exercise, and fast food consumption were associated with an increased temporal risk of acute coronary syndromes (e.g., infection OR 7.5; P=0.002).
Why the study?
Do precipitants such as infection, inflammation, exercise, and fast food consumption increase the immediate risk of acute coronary syndromes?
Population
348 patients with ST-elevation myocardial infarction (44%) or high-risk non-ST-elevation ACS (56%)
Comparison
Exposure to potential precipitants: infection… vs Control periods within the same patients
Design
Case-control
Authors
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Infection may precipitate ACS via inflammation; leaves open causal prevention strategies in observational data.
Case-Control (n=348)
Do precipitants such as infection, inflammation, exercise, and fast food consumption increase the immediate risk of acute coronary syndromes?
Odds Ratio: 7.5 (95% CI 1.7–67.6)
p-value: p=0.002
Infection, inflammatory conditions, moderate-heavy exercise, and fast food consumption appear to act as immediate precipitants for high-risk acute coronary syndromes, though not all are associated with elevated systemic CRP.
Chew et al. (2011) conducted a case-control in Acute coronary syndromes (STEMI or high-risk NSTE-ACS) (n=348). Precipitants (infection, inflammation, exercise, fast food) vs. Control periods (e.g., 7-8 weeks prior, 24-28 hours prior) was evaluated on Temporal risk of acute coronary syndrome (infection precipitant) (OR 7.5, 95% CI 1.7-67.6, p=0.002). Recent infection, inflammatory conditions, moderate-heavy exercise, and fast food consumption were associated with an increased temporal risk of acute coronary syndromes (e.g., infection OR 7.5; P=0.002).
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