What question did this study set out to answer?

To assess the relationship of EGFR gene copy number, protein expression, mutations, and Akt activation status with gefitinib sensitivity in advanced NSCLC.

May 3, 2005JNCI Journal of the National Cancer InstituteOpen Access

Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer

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Authors

FCFederico CappuzzoIstituti Fisioterapici Ospitalieri FHFred R. HirschMount Sinai Health System ERElisa RossiIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola

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Implication

Randomized trial evaluates gefitinib response in NSCLC patients, suggesting EGFR status predicts outcomes.

Key Points

To assess the relationship of EGFR gene copy number, protein expression, mutations, and Akt activation status with gefitinib sensitivity in advanced NSCLC.
Evaluated tumors from 102 advanced NSCLC patients treated with 250 mg gefitinib daily.
Analyzed EGFR status using fluorescence in situ hybridization (FISH), DNA sequencing, and immunohistochemistry for Akt activation.
Calculated time to progression and overall survival using Kaplan-Meier and log-rank tests.
EGFR gene amplification or high polysomy seen in 33 of 102 patients linked to improved response (36% vs 3%, P<.001) and survival (18.7 vs 7.0 months, P=0.03).
High protein expression found in 58 of 98 patients associated with better disease control (67% vs 26%, P<.001).
High EGFR copy number remained significant in multivariable analysis with a hazard ratio of 0.44 (P=0.03).

Cite This Study

Cappuzzo et al. (2005) studied this question.

synapsesocial.com/papers/6a5d0841fbfab74aebc2410e https://doi.org/10.1093/jnci/dji112

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Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer

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Cite This Study

Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer

Discussion

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Implication

Key Points

Cite This Study

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