May 19, 2006American Journal of Roentgenology
Diagnostic Performance of MDCT for Detecting Aortic Valve Regurgitation
Key result
16-MDCT coronary angiography detected aortic regurgitation with an overall sensitivity of 81% and specificity of 91%, rising to 95% and 96% for moderate and severe cases.
Why the study?
Does ECG-gated 16-MDCT coronary angiography accurately detect aortic regurgitation compared to Doppler TTE in patients evaluated for AR?
Population
71 patients evaluated prospectively for aortic regurgitation
Comparison
ECG-gated 16-MDCT coronary angiography using… vs Doppler transthoracic echocardiography based on…
Design
Cross-sectional
Authors
Discussion
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Overview
May support 16-MDCT for moderate-severe AR detection; leaves open prospective validation before practice change.
Study Design
Type
Cross-Sectional (n=71)
Structured PICO
Does ECG-gated 16-MDCT coronary angiography accurately detect aortic regurgitation compared to Doppler TTE in patients evaluated for AR?
P
Population
71 patients evaluated prospectively for aortic regurgitation using 16-MDCT compared to Doppler TTE.
E
Exposure
ECG-gated 16-MDCT coronary angiography using retrospective ECG gating during the mid-to-end diastolic phase
C
Comparator
Doppler transthoracic echocardiography (TTE) based on semiquantitative regurgitation jet analysis
O
Outcome
Diagnostic performance (sensitivity, specificity, positive predictive value, negative predictive value) for detecting aortic regurgitationsurrogate
Main Result
Effect estimate: Sensitivity 81%, Specificity 91%
16-MDCT coronary angiography is an accurate noninvasive tool for detecting moderate to severe aortic regurgitation, but its utility is limited in mild cases and by severe valve calcification.
Limitations
- Severe valve calcifications preventing quantification in 50% of cases
- Limited accuracy for mild aortic regurgitation
- severe valve calcifications
- mild AR limits results
Cite This Study
Feuchtner et al. (2006) conducted a cross-sectional in Aortic regurgitation (n=71). 16-MDCT coronary angiography vs. Doppler TTE was evaluated on Detection of aortic regurgitation (Sensitivity 81%, Specificity 91%). 16-MDCT coronary angiography detected aortic regurgitation with an overall sensitivity of 81% and specificity of 91%, rising to 95% and 96% for moderate and severe cases.