Key result
Animal toxins can alter the function of Nav1.8 and Nav1.9, which are preferentially expressed in DRG neurons and play an important role in pain signaling.
This review highlights the pharmacological targeting of Nav1.8 and Nav1.9 channels by animal toxins to better understand their gating properties and role in pain signaling.
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Supports toxin-based probes for Nav1.8/Nav1.9 pain research; leaves open clinical translation.
Gilchrist et al. (2012) conducted a review in Pain perception. Animal toxins was evaluated. Animal toxins can alter the function of Nav1.8 and Nav1.9, which are preferentially expressed in DRG neurons and play an important role in pain signaling.
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