Key result
An estimated glomerular filtration rate <71.5 mL/min/1.73 m2 was an independent predictor of left atrial low-voltage areas in patients with atrial fibrillation undergoing catheter ablation (OR 3.3).
Why the study?
Residual left atrial low-voltage areas predict AF recurrence after pulmonary vein isolation and CKD increases recurrence, but the association between CKD and low-voltage areas has not been elucidated.
Is chronic kidney disease severity associated with the prevalence of left atrial low-voltage areas in patients with atrial fibrillation undergoing catheter ablation?
Observational (n=183)
No
Is chronic kidney disease severity associated with the prevalence of left atrial low-voltage areas in patients with atrial fibrillation undergoing catheter ablation?
Odds Ratio: 3.3 (95% CI 1.4–7.8)
p-value: p=0.006
Chronic kidney disease severity is independently associated with the presence of left atrial low-voltage areas in patients undergoing atrial fibrillation ablation, potentially explaining higher recurrence rates in this population.
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Renal dysfunction may flag higher LVA burden in AF ablation candidates; extends observational links to recurrence but leaves causality and intervention targets open.
Matsuda et al. (2019) conducted an observational in Atrial Fibrillation (n=183). Estimated glomerular filtration rate <71.5 mL/min/1.73 m2 vs. Estimated glomerular filtration rate ≥71.5 mL/min/1.73 m2 was evaluated on Presence of left atrial low-voltage areas (LVA) (OR 3.3, 95% CI 1.4-7.8, p=0.006). An estimated glomerular filtration rate <71.5 mL/min/1.73 m2 was an independent predictor of left atrial low-voltage areas in patients with atrial fibrillation undergoing catheter ablation (OR 3.3).
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