Key result
CYP2C9 and VKORC1 polymorphisms and age are significant determinants of the maintenance dose of warfarin, whereas medical indications are not.
Why the study?
Do CYP2C9 and VKORC1 genotypes and age determine the maintenance dose of warfarin in Han-Chinese patients?
Observational (n=180)
No
Do CYP2C9 and VKORC1 genotypes and age determine the maintenance dose of warfarin in Han-Chinese patients?
CYP2C9 and VKORC1 genotypes, along with age, significantly determine warfarin maintenance dose requirements in Han-Chinese patients, independent of the clinical indication.
Answers are grounded in this paper and cite their sources.
May support genotype- and age-informed warfarin dosing; extends associations to Han-Chinese but leaves practice unchanged pending trials.
AIMS: have different effects on the dose of warfarin in 180 Han Chinese patients who were recruited from the Fu Wai Hospital. All were on maintenance treatment with stable daily warfarin doses for a period of at least 3 months. METHODS: . RESULTS: were not dependent on the medical indication(s) present. The medical indications atrial fibrillation, valve replacement, or a combination of both are not determinants of the warfarin dose requirements.
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Chen et al. (2016) conducted an observational in Patients on maintenance warfarin therapy (n=180). CYP2C9 and VKORC1 polymorphisms was evaluated on Maintenance dose of warfarin. CYP2C9 and VKORC1 polymorphisms and age are significant determinants of the maintenance dose of warfarin, whereas medical indications are not.
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