Key result
COVID-19 and its associated physical and emotional stressors can trigger Takotsubo syndrome, with 119 cases reported to date.
Why the study?
Randomized studies on COVID-19 related Takotsubo syndrome are lacking, and its pathogenesis and pathophysiology remain unclear.
This review provides an overview of the pathogenesis, clinical manifestations, diagnosis, and treatment strategies for Takotsubo syndrome in patients with COVID-19.
TTS in COVID-19 is hypothesis-generating; leaves open incidence, mechanisms, and whether recognition alters outcomes.
The novel coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global public health emergency. As the number of confirmed cases increases, cardiovascular complications, such as myocardial injury and cardiac dysfunction, are evidenced. Takotsubo syndrome (TTS), which is common in the intensive care unit, is diagnosed among COVID-19 patients. There have been 68 more cases reports with over 119 patients since a COVID-19 patient with TTS was first reported on April 14, 2020. Angiotensin-converting enzyme 2 (ACE2), which is widely expressed in the lungs and heart, is the virus receptor. Nevertheless, randomized studies on COVID-19 related TTS are lacking, and the pathogenesis and pathophysiology are still unclear. Therefore, this review provides an overview of the potential pathogenesis, pathophysiology, clinical manifestations, diagnosis, and treatment strategy for TTS in the COVID-19 era based on current practices.
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Zhou et al. (2022) conducted a review in COVID-19-related Takotsubo Syndrome (n=119). COVID-19 was evaluated. COVID-19 and its associated physical and emotional stressors can trigger Takotsubo syndrome, with 119 cases reported to date.
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